The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background
Figure 7
Analysis of insulin sensitivity in female C57BL/6J Slc30a8 KO mice in vivo.
Insulin tolerance tests were performed on 5 hr fasted conscious C57BL/6J WT (closed symbols) and Slc30a8 KO (open symbols) female mice as described in Materials and Methods. Results show the mean glucose concentrations ± S.E.M. in WT (n = 8; mean age ∼18 weeks) and Slc30a8 KO (n = 8; mean age ∼18 weeks) animals. In these groups of mice the initial glucose concentration at time zero was higher in KO mice (142.6±6.1 vs 120.8±4.9 mg/dl; p<0.02).