Iontophoresis of Endothelin Receptor Antagonists in Rats and Men
Figure 3
Effect of iontophoresis of bosentan 10
−2 M, sitaxentan 10 −2 M and NaCl 0.9% on skin blood flux during infusion of i.a. endothelin 0.5 10 −5 M in rats, expressed as arbitrary perfusion units mean (mean±SEM), in the cathodal direction ( Fig 3A ) and anodal direction (Fig. 3B).