Molecular Profiles of HCV Cirrhotic Tissues Derived in a Panel of Markers with Clinical Utility for Hepatocellular Carcinoma Surveillance
Figure 1
Schematic representation of the study design.
HCV-cirrhotic tissue samples were divided in two main groups: 1) microarray hybridization (n = 80), and 2) independent validation set (n = 27), represented in gray squares. Pairwise comparisons among woHCC, wHCC, and iHCC groups of hybridized microarrays were performed for molecular pathway analyses. L1-penalized regression model was fit for woHCC and wHCC groups with hybridized microarrays (training set). The iHCC group was the test set for the identified prediction model. The independent set (n = 27) validated the expression of 9 randomly selected genes from the prediction model.