The Role of Platelet Factor 4 in Local and Remote Tissue Damage in a Mouse Model of Mesenteric Ischemia/Reperfusion Injury
Figure 2
Intestinal and lung injury is reduced after mesenteric ischemia/reperfusion in PF4-/- mice:
Hematoxylin and eosin stained sections of mouse small intestine and lung after 30 minutes of ischemia and 3 hours reperfusion. A total of 5–8 mice were used for each control and experimental groups in two experiments. (A-D) Images of lung from sham and IR (E-H). Images of intestinal villi from sham and IR. All images shown are 200× magnification. (I,J) Injury score (mean ± SD) in lung and intestine.(K) PF4 plasma levels in B6 and PF4-/- mice before and after mesenteric IR injury. *p≤0.05, **p≤0.01, and ***p≤0.001 for IR compared to sham controls.