Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons
Figure 6
Diabetes reduced the slowly inactivating A-type current (IAS) in capsaicin-sensitive neurons.
(A, B) I-V relations were obtained for peak (A) and steady-state (B) IAS from diabetic (n = 12, filled circles) and control (n = 14, open circles) small DRG neurons. (C) The voltage-dependent activation and inactivation curves for peak IAS from diabetic (n = 12 and 10, filled circles) and control (n = 14 and 12, open circles) neurons are shown. (D) The voltage-dependent activation curve for steady-state IAS from diabetic (n = 11, filled circles) and control (n = 7, open circles) neurons are displayed. (E) The activation time constant τm of IAS from diabetic (n = 6, filled circles) and control (n = 5, open circles) neurons was measured. The time constants of IAS were increased in diabetic neurons. (F) The inactivation time constants (τ1, τ2) of IAS from diabetic (n = 6, filled circles) and control (n = 5, open circles) neurons are plotted. τ1 is the slower time constant. τ2 is the faster time constant. * represents a significant difference between diabetic and control groups by a one–way ANOVA. All data are represented as mean ± S.E.M.