Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1
Figure 1
PP1 with RVxF peptide bound to its hydrophobic channel.
Peptide RRVSFA derived from Gm protein, a regulatory subunit of PP1 involved in glycogen metabolism, shown in ball-and-stick representation and colored after the CPK scheme, with carbon atoms colored in green for clarity. Solvent accessible surface area around the RVxF binding site is shown in transparent, and colored according to electrostatic potential.