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Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses

Figure 4

Presents the evolution of the cumulative I2 estimates and their associated 95% confidence intervals (CIs) over the accumulation of trials in meta-analyses (9) to (16).

The cumulative I2 are represented by the dot-dashed line ( ), and their associated cumulative 95% CIs are represented by the dotted lines ( ).

Figure 4

doi: https://doi.org/10.1371/journal.pone.0039471.g004