Alopecia in a Viable Phospholipase C Delta 1 and Phospholipase C Delta 3 Double Mutant
Figure 6
Histological aspects of oltSH mutants on postnatal day 12.
Methacrylate (Technovit 7100) sections of representative areas in the dorsal skin on postnatal day 12 oltSH mice, HE stain, bar = 100 µm in A, bar = 25 µm in B to D. Boxed areas in A are shown at higher magnification B, C, and D respectively. Four different animals were investigated. A. The overview shows hair follicles in anagen (box B) and catagen (box C) side by side. B. The hair follicle shows active melanogenesis as a hallmark of anagen (arrowhead). C. The hair follicle is in catagen and has excluded the dermal papilla (arrowhead). D. Accumulations of neutrophilic granulocytes (arrowhead) are seen in the vicinity of follicles in catagen.