Investigation of the Acetylation Mechanism by GCN5 Histone Acetyltransferase
Figure 12
Overall structure of GCN5/H3/AcCoA complex and the interactions.
Two important loops involved in H3 binding, α1-α2 loop and α1-β7 loop are illustrated. Hbond interactions indicate those residues in hydrogen bonds with H3, which are displayed in yellow dashed lines in left enlarged figure; hydrophobic interactions presented in right enlarged figure indicate those residues forming hydrophobic interactions with H3 to provide appropriate reaction environment.