Cystatin A, a Potential Common Link for Mutant Myocilin Causative Glaucoma
Figure 4
MYOC mutants induced changes on genes of trabecular meshwork relevant functions, especially on the UPR.
Heat maps of set of genes representing four relevant trabecular meshwork functions. The four categories gene lists were costumed generated by literature review. Each row represents the fold change (Adeno.MYOC mutant over Adeno.Null) for a single gene in each of the four mutants. Each column represents the fold changes for all genes of the category in one MYOC mutant. The fold change for each gene is visually represented by a color, which is given by the scale bar in the center of the figure. Heat maps were generated with genes lists containing the full range of fold changes. Gray cells indicate that the expression of the giving gene was below the signal intensity cutoff value and was considered absent.