Aliskiren Prevents the Toxic Effects of Peritoneal Dialysis Fluids during Chronic Dialysis in Rats
Figure 2
Aliskiren decreases fibrosis markers and inhibits changes in apoptosis markers induced by peritoneal dialysis fluids (PDFs) in rat peritoneal mesothelial cells (PMCs).
Cells were treated for 24 h with a 1.5%-glucose PDF diluted 1∶1 in culture medium in the absence (V) or the presence of aliskiren, and the levels of mRNA for p53 (a), Bax (b), Bcl-2 (c), collagen III (d) and fibronectin (e) were determined by real-time RT-PCR. Data represent mean ± s.e.m. of 4 experiments. *p<0.05 as compared to untreated control cells (C). #p<0.01 as compared to cells treated with vehicle and PDF (V).