3,3′-Diindolylmethane Induces G1 Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells
Figure 5
DIM induces apoptosis in human T-ALL cells.
CEM, HSB2, SUP-T1 and Jurkat cells were treated with 3.8 to 15 µM DIM for 48 hr. Values are the proportion of apoptotic cells as determined using the ViaCount assay + SEM (n = 3 to 4 independent experiments). *, p<0.05; **, p<0.01 or *** p<0.001 for compared to the vehicle control (0 µM DIM, 0.1% DMSO) as determined by one-way RM ANOVA (matching by experiment day) with Dunnett's multiple comparisons post-hoc test.