Inhibition of Enterovirus 71 (EV-71) Infections by a Novel Antiviral Peptide Derived from EV-71 Capsid Protein VP1
Figure 1
Identification of antiviral peptides.
A library consisting of 95-overlapping peptides (15 mers) covering the entire EV-71 capsid protein, VP1 was synthesized. Each peptide was screened at a presumptive concentration of 100 µM for its ability to inhibit EV-71 infection in plaque reduction assay. The top line showed a schematic representation of the EV71 genome, and the activities of the peptides were shown at the bottom. Arrows denote the four peptides that were positive in the assay.