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Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects

Figure 13

Illustration of a re-entrant dose response predicted by the thermostatistical model for a double-binding-site promoter using the measure of synergy suggested by Chi and Carey (1996).

The graph represents the measure of synergy proposed by Chi and Carey [15] calculated from the ‘DS’ and ‘2× SS’ graphs shown in Figure 9. After reaching a peak value the graph decays monotonically as a function of and leaves the greater-than-additive response domain at a certain critical transcription factor concentration. Such a behavior was observed in experiments by Chi and Carey on a promoter with seven binding sites, see Figure 1G–H.

Figure 13

doi: https://doi.org/10.1371/journal.pone.0034439.g013