Natural Terpenes Prevent Mitochondrial Dysfunction, Oxidative Stress and Release of Apoptotic Proteins during Nimesulide-Hepatotoxicity in Rats
Figure 2
Determination of nimesulide-induced hepatotoxicity. A.
Clinical biochemistry (levels of SGPT, SGOT and bilirubin) of blood serum. B. Histopathology of H&E stained liver tissue of vehicle control (i), nimesulide administered rats (ii) and CG pre-administered rats (iii). Pictures were taken at 125X (i, ii, and iii) and 500X (iv, v and vi) magnification. In figures yellow arrow heads represent normal hepatocytes; red arrowhead represents edema, green arrowhead represents hyperplastic bile ductule, and white arrowheads represent degenerating hepatocytes with infiltration of inflammatory cells. Level of significance is denoted as */# P<0.05, **/## P<0.01 and ***/### P<0.001. *, compared to vehicle control and #, compared to nimesulide stress.