Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
Figure 3
Association of SNP rs12603825 with fasting plasma leptin concentration (A), total adipose tissue mass (B), and fasting plasma PEDF concentration (C).
Adjusted data (means +SE) of the dominant inheritance model (GG versus GA+AA) are presented. Total adipose tissue (AT) mass was measured by magnetic resonance imaging (N = 340), plasma leptin (N = 1,409) and PEDF (N = 340) by enzyme-linked immunosorbent assays (see Materials and Methods).