Dynamics of Adrenal Steroids Are Related to Variations in Th1 and Treg Populations during Mycobacterium tuberculosis Infection in HIV Positive Persons
Figure 3
Analysis of Treg population across the spectrum of TB infection.
Percentage of Treg cell populations (A. CD4+FoxP3+CD25+ Treg, B. CD4+FoxP3+CD25- Treg and C. CD4+FoxP3+ Treg) of HIV-TB (n = 11), HIV+ (n = 7), HIV-LTB (n = 4), IRIS (n = 5) and HD (n = 10) individuals. D. Representative data for Treg flow cytometric analysis from HIV-TB (upper left), IRIS (upper center), HIV (upper right), HIV-LTB (lower left) and HD (lower right) individuals. The plots shown were gated first on lymphocytes by scattering properties, then on CD4+ T cells and finally analyzed for expression of CD25 and FoxP3. A, B and C. For the box and whisker plots, the horizontal line represents the median, the boxes represent the interquartile range and the whiskers represent the minimum and maximum values. Asterisks indicate comparisons between groups. *: p < 0.05; **: p < 0.01; ***: p < 0.001.