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Deletion of Porcn in Mice Leads to Multiple Developmental Defects and Models Human Focal Dermal Hypoplasia (Goltz Syndrome)

Figure 3

Phenotype at E9.5 and gene expression analysis of XPorcn-ex3-7del/X embryos.

(A) XPorcn-ex3-7del/X embryo with open neural tube and abdominal wall closure defect (arrows). (B) Bar graph of quantitative real-time PCR analysis at E9.5 (top panel) and E10.5 (bottom panel) of Porcn wild type (n = 4 each) and mutant (n = 3 each) embryos. Bars are color-coded by gene type and indicate the log2 of the fold-deviation of gene expression levels in Porcn mutant embryos compared to wild type (set as 1). Error bars indicate standard errors of the mean. (*) indicates statistical significance at p<0.05 (Student's t-test).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0032331.g003