Skeletal Muscle PGC-1α Is Required for Maintaining an Acute LPS-Induced TNFα Response
Figure 2
TNFα mRNA and protein content in quadriceps.
Tumor necrosis factor (TNF)α mRNA and protein in quadriceps muscle from whole body PGC-1α knockout (KO) (A,D), muscle specific PGC-1α KO (MKO) (B,E) and muscle specific PGC-1α overexpression (TG) mice (C,F) and their respective littermate wild type (WT) mice, 2 hours after injection with either saline (Sal) as control or lipopolysaccharide (LPS). Values are presented as means ± S.E. with n = 10 in each group. *: Significantly different from Sal within given genotype, p<0.05. #: Significantly different from WT within given treatment, p<0.05.