Lower Respiratory Tract Infection Induced by a Genetically Modified Picornavirus in Its Natural Murine Host
Figure 12
Effect of inhalation of attenuated mengovirus on pulmonary physiology.
Mice received intranasal inoculations of vehicle, 106 PFU of attenuated mengovirus, vMC0 (n = 6–7 mice per group), or an equivalent amount of UV-inactivated vMC0 (n = 4 mice), and on day 2 postinoculation, pulmonary physiology measurements were obtained after exposure to aerosols of normal saline followed by escalating concentrations of methacholine. Values for respiratory system resistance (Rrs) are presented as the group means ± the standard error. There were no significant differences among the groups.