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Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model

Figure 7

Immunohistological and fluorescent analysis of tumor sections.

The upper panels display sections stained with antibodies against EGFR (A), GLUT-1 (B), MMP-9 (C) and CathepsinB (D). The lower panels show the corresponding sections with FLI signals from animals injected with IRDye 800CW EGF (E), IRDye 800CW 2-DG (F), MMPSense680 (G) or ProSense680 (H). Scale bar = 2 mm.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0031875.g007