Successful Shortening of Tuberculosis Treatment Using Adjuvant Host-Directed Therapy with FDA-Approved Phosphodiesterase Inhibitors in the Mouse Model
Figure 3
Cytokines profile of PDE-I monotherapy of C3HeB/FeJ infected mice.
The administration of cilostazol and sildenafil decreases proinflammatory cytokine levels in the lungs of M.tb.-infected mice. C3HeB/FeJ mice infected with 3.67 log10CFU M.tb. were treated daily by oral gavage (starting the day after infection) with 10 mg/kg cilostazol (C10) or sildenafil (S10). At 25 days post-infection, lungs were homogenized, and the concentrations of TNF-α, IFG-γ, GM-CSF, IL-10 and IL17 were determined.