An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation
Figure 3
Changes in optic disc and [11C]PK11195 PET image in coronal slices from cynomolgus monkeys at a moderate stage after laser photocoagulation.
(A) Accumulation of [11C]PK11195 binding potential in the LGN before and 4 weeks after laser photocoagulation. Coronal planes at the level of the LGN are shown. The PET images are shown in color, overlaid on the template MRIs is shown in gray scale. The color scale on the right represents standard uptake value (SUV). (B) Binding potential values of the right and left LGN obtained from 4 different individuals (4 monkeys; #2, #3, #4, #5, seen in tables 1 and 2). White and black column indicate pretreatment (pre) and post treatment (post) periods, respectively, for the laser photocoagulation. Each column represents the mean ± S.E.M. (n = 4). *p<0.05 versus the pretreatment.