Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide
Figure 2
Bactericidal activities of 2 and 3-drug combinations against intracellular M. tuberculosis in whole blood culture.
Negative values in these blocks indicate killing. A color gradient has been applied to indicate green as bacterial growth, and red as death. The difference from sum was determined by subtracting the activity predicted as the sum of both compounds tested individually from that observed when tested in combination. Positive values here indicate combinations less active than predicted. TMC207 and SQ109 showed additive activity when combined with PNU-100480. Combinations of PA-824 with either PNU-100480 or TMC207, or as a 3-drug combination, were less than additive.