Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation
Figure 5
Loss of Bmp7 results in a decrease in cell proliferation in the cloacal regions, and defects in epithelial stratification.
(A, B) Sagittal sections of wild type (A) and Bmp7 null (B) cloacal regions at E11.5 were immunolabed for pHH3, and nuclei stained with DAPI. Scale bars, 50 µm. Framed areas of the cloacal endoderm are shown at high magnification in the insets. Arrows indicate the width of the cloacal epithelium. (C) Graph presents the average number of pHH3+ cells in a 100 µm2 square in the cloacal endoderm (ce), URM and genital mesenchyme (gm). Student's t-test: *P<0.01.