Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression
Figure 6
Knockdown of Hspb11 results in slow muscle myosin disorganization in skeletal muscles.
(A, D and G) mmMO-hspb11 injected embryos. (B, E and H) MO(ATG)-hspb11 morphants. (C, F and I) MO(UTR)-hspb11 morphants. (A–C) Phenotypic observations of morpholino injected embryos at 48 hpf. (D–E) Muscle organization determined with birefringence at 72 hpf. (G–I) Slow muscle myosin distribution at 72 hpf shown by immunofluorescence staining with antibody F59. Arrows indicate gaps in fiber distribution.