MAP4 Mechanism that Stabilizes Mitochondrial Permeability Transition in Hypoxia: Microtubule Enhancement and DYNLT1 Interaction with VDAC1
Figure 5
MAP4 overexpression contributes to cellular viability (measured by MTT) and energy metabolism maintenance (measured by ATP) during hypoxia.
A, MTT reduction in +MAP4 groups (CMs and HeLa cells) was less when compared with Con (non-transfected) cells. B, ATP reduction in +MAP4 groups was also less when compared with Con cells. Values were compared to normal values (Norm; first bar), which were set to 100% and the other values normalized accordingly. Graph represents the mean±SEM (n = 6, Separate six experiments) of the relative luminescence signals. * P<0.05, # P<0.01 vs. Con.