Naturally Occurring Variants of Human Α9 Nicotinic Receptor Differentially Affect Bronchial Cell Proliferation and Transformation
Figure 1
Structure and splicing of human CHRNA9 gene.
A. Structure of the human CHRNA9 gene. Exons are shown as rectangles and introns are shown as lines. B, C, D, E. Variants of the splicing of mRNA coded by the CHRNA9 gene detected in BEP2D cells. The mRNAs for full-length (B) and truncated proteins (C, D, E) expressed in BEP2D cells. The truncated α9 used in overexpression experiments resulted from a loss of the exon 4 that causes frame shift with 122 aa peptide translation (C).