Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse
Figure 2
Infarct size, apoptosis and left ventricular remodeling in wild-type and IL-1R1-/- mice.
When compared with the corresponding wild-type mice, infarct scar size (Masson's trichrome stain) and cardiomyocyte apoptotic rate (in-situ end labelling of DNA fragmentation–TUNEL) were significantly smaller in IL-1R1-/- mice. Moreover, IL-1R1-/- mice had less left ventricular enlargement and systolic dysfunction 1 week after AMI. N = 6–8 per group.