Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection
Figure 4
Median joining (MJ) haplotype network for bovine TLR10 using haplotypes predicted for all cattle (n = 96 AI sires, 31 breeds; 48 Purebred Angus; 405 Holstein cattle).
Haplotypes predicted for B. t. taurus, B. t. indicus and hybrids (termed “composites”) are color coded. Numbers indicate SNP positions in numerical order (see Table S2 for SNP information). Node sizes are proportional to haplotype frequency, and all branch lengths are drawn to scale. Alphabetized letters at nodes represent the breed distribution of each haplotype (Table S4). Notably, given the complexity of the network, only nodes representing≥10 cattle are labeled (A-F), which collectively represents>93% of the cattle meeting the phase requirements (n = 524 cattle with best-pair probabilities≥0.90). Median vectors are indicated as “mv”.