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The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

Figure 5

Characterization of key residues for the recognition of the histone H3 tail by huUHRF1-PHD296–367.

ITC quantification of the effect of introducing point mutations at residue Q330, which interacts with H3K4, or at the two residues D334 and D337, that bind to H3R2. The Kd values for the mutants Q330K and D334AD337A could not be determined because no binding signal was detected with the H3 peptide.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0027599.g005