Mild Functional Differences of Dynamin 2 Mutations Associated to Centronuclear Myopathy and Charcot-Marie-Tooth Peripheral Neuropathy
Figure 8
Effect of dynamin 2 mutations on Golgi network morphology.
(A) Overexpression of CNM and CMT dynamin 2 mutants does not impact on Golgi morphology. COS-1 cells expressing ectopic dynamin 2 constructs were fixed in paraformaldehyde and were stained with anti-dynamin 2 and anti-golgin 97 antibodies. (B) Golgi network morphology is comparable between control and patient fibroblasts harboring CNM mutations. Fibroblasts were fixed in paraformaldehyde and were stained with anti-GM130 antibodies and Hoechst.