Mll5 Is Required for Normal Spermatogenesis
Figure 2
Abnormal spermatozoa in epididymides of homozygous Mll5tm1Apa mice.
Comparison of representative spermatozoa and sections of the epididymides from wild-type (A-C) and Mll5 -/- (E-F) mice. (A, D) Fluorescence microscopy of spermatozoa from the cauda epididymis and vas deferens with DNA stain (propidium iodide). Abnormally shaped sperm nuclei are arrowed in D. PAS staining shows an excess of cytoplasmic droplets (arrowed) in the cauda epididymides of the mutant males. Original magnification×100 (A–E) while (C, F) are digitally magnified from (B, E) respectively.