Expansion of Intestinal Epithelial Stem Cells during Murine Development
Figure 3
ISC marker mRNA expression in WT mice and percent SP cells at p21 and adulthood.
For panels A–E, the x-axis represents postnatal age in days and the y-axis represents fold change in mRNA expression compared with β-actin. Markers for the CBC subpopulation are shown in the left (panels A, C, and E), whereas markers for the “plus 4” ISC subpopulation are shown on the right (panels B and D). Panel F shows the percentage of CD45− side population (%SP) from p21 and adult animals. For all panels, data are given as means ± SE (n = 3–6) and * indicates values significantly higher than adult (p<0.01) whereas ** indicates values significantly lower than adult (p<0.01). Data for the entire statistical analysis of the mRNA data are shown in Supplemental Table 1.