Common Genetic Variants Are Associated with Accelerated Bone Mineral Density Loss after Hematopoietic Cell Transplantation
Figure 2
Annualized rate of bone mineral density change after hematopoietic cell transplantation by the number of risk alleles of the SNPs significant in the multiple SNP models.
Mean and standard error of annualized rate of BMD change is plotted by the number of risk alleles in significant SNPs from the multiple SNP models as shown in Table 3. The p-values for a trend between the number of risk alleles and BMD change were ≤0.003 for all three outcomes. The proportion of HCT patients carrying the specified number of risk alleles is shown. The multiple SNP analysis was not performed for spinal BMD change after allogeneic HCT since only one SNP was significant in the multiple SNP model. Please refer to Table S2 for a description of these genes and SNPs. Abbreviation: BMD, bone mineral density; HCT, hematopoietic cell transplantation; SNP.