Mechanism of Salutary Effects of Astringinin on Rodent Hepatic Injury following Trauma-Hemorrhage: Akt-Dependent Hemeoxygenase-1 Signaling Pathways
Figure 1
Effect of astringinin treatment on plasma AST (A) and ALT (B) in rats after sham operation (Sham) or trauma-hemorrhage and resuscitation (T-H).
Animals were treated with vehicle (Veh), astringinin (Ast), astringinin in combination with wortmannin (Ast+W), wortmannin (W), astringinin in combination with chromium-mesoporphyrin (Ast+C), or chromium-mesoporphyrin (C). Data are shown as mean ± SEM; n = 8 rats in each group. *p<0.05 compared with sham; #p<0.05 compared with T-H+Veh, T-H+Ast+W, T-H+W, T-H+Ast+C, and T-H+C.