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Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

Figure 3

APP was expressed in hiPS cell-derived neuronal cells.

HiPS cell-derived neuronal cells express full-length APP, sAPPα, sAPPβ, APP-CTFα, APP-CTFβ and AICD at 38, 45, and 52 days. (A) Representative western blots of APP and its fragments. (B) Each column represents mean ± SD of 8 samples measured by quantitative western blot analysis and normalized by that of β-actin. “Fold expression” represents the ratio of expression on the given day compared to day 38. *p<0.05, **p<0.01, ***p<0.001, Tukey's test.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0025788.g003