A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses
Figure 6
Immunization with MVA-B ΔC6L enhances the humoral immune responses elicited against HIV-1 gp160 protein.
Serum was collected from individual mouse immunized with DNA-B/MVA-B, DNA-B/MVA-B ΔC6L or DNA-φ/MVA (n = 4 in DNA-B/MVA-B and DNA-φ/MVA; n = 3 in DNA-B/MVA-B ΔC6L), 53 days after the last immunization. Anti-gp120 antibody titers were determined by ELISA as described in Materials and Methods. Titers represent the last dilution of the serum that signals 3-fold higher than signals obtained with the serum of naïve mice. The dotted line represents the limit of detection of the ELISA. The horizontal bar represents the mean value. Each dot represents one mouse. * p<0.05.