ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function
Figure 4
Increased BP, autonomic dysfunction and oxidative stress in mature ACE2−/y mice.
Baseline MAP was significantly increased in mature ACE2−/y compared to age-matched NT mice (A). Increased sympathetic (B) and decreased parasympathetic (C) tones were also observed in ACE2−/y mice (*P<0.05 vs. NT). In addition, vascular sympathetic tone in ACE2−/y mice was significantly elevated compared to NT (D; *P<0.05 vs. NT). Moreover, oxidative stress was exacerbated in the several brain regions (SFO: subfornical organ, PVN: paraventricular ncleus, NTS: nucleus of the tractus solitarius, RVLM: rostral ventrolateral medulla and AP: area postrema) of mature ACE2−/y compared to NT mice (E; *P<0.05 vs. NT).