Exploring and Exploiting Disease Interactions from Multi-Relational Gene and Phenotype Networks
Figure 2
The Phenotypic and Genetic Disease Networks.
(A) The phenotypic disease network (PDN) is constructed based on clinical history of 700,00 patients. Each node represents a unique disease, and two nodes are connected if the diseases co-morbid significantly more than randomly expected according to population prevalence. (B) The genetic disease network (GDN) is constructed on the same disease nodes, but edges instead indicate that the disease pair shares a significant number of gene associations. In both networks, black edges indicate hierarchically related diseases (is-a relationships). For each network, the accompanying table displays the most relevant Disease Ontology codes associated with each cluster. Purity corresponds to the percent of member nodes which are accurately described by the DO term, and completeness indicates the percentage of descendants of the DO term which belong to the cluster. For a detailed definition, see Materials and Methods. It is clear that the PDN and GDN are structurally different. Nonetheless, both networks form some easily defined clusters but also have some dense regions containing diverse DO terms.