Cold-Adapted Influenza and Recombinant Adenovirus Vaccines Induce Cross-Protective Immunity against pH1N1 Challenge in Mice
Figure 4
Vaccine effectiveness in protection against challenge with ma-CA/04. Groups of BALB/c (A and B) or B6 (C and D) mice were immunized as in Figure 1, or left unvaccinated. Three weeks after immunization, animals were challenged with 5 MLD50 of ma-CA/04 intranasally and monitored for survival (A and C) and weight loss (B and D). Weight loss graph shows average of n = 9 (BALB/c) or n = 12 (B6) mice ±SD. * P≤0.0001 versus naïve; log rank test (A and C); or P≤0.01 versus naïve; two-way repeated measures ANOVA with Holm-Sidak post-test (B and D). No statistically significant differences were found between NP+M2-rAd and ca vaccine.