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Chlamydia pneumoniae Infection Induced Allergic Airway Sensitization Is Controlled by Regulatory T-Cells and Plasmacytoid Dendritic Cells

Figure 7

pDC depletion allows high dose CP infection induced antigen sensitization.

A–D: WT mice received either CP+mAB 927 (n = 9), CP+IgG control (n = 8), PBS+mAB 927 (n = 10), or PBS+IgG control (n = 8), and were sensitized and challenged with HSA as described in Figure 1E. A: Representative flow cytometric analysis of pDC depletion the day after mAB 927 injection. pDCs are indicated in the gated population. Inflammation (B), Eosinophils (C) and Goblet cells (D) were scored for as before. *p≤0.05, **p≤0.01, ***p≤0.001.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0020784.g007