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HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes

Figure 3

HSPB6, HSPB7, HSPB8 protective effect is independent of HSPB1.

(A) Western blot showing efficient siRNA-induced HSPB1 knockdown in HL-1 mycoytes. (B) Recordings of CaT for mock and siRNA construct. HL-1 myocytes were transfected with mock or siRNA construct for 5 days before study. One day before tachypacing, the myocytes were transfected with HSPB6, HSPB7 or HSPB8 and subjected to normal pacing (1 Hz) or tachypacing (4 Hz). (C) Mean CaT data. The cardioprotective effect of HSPB6, HSPB7 or HSPB8 was not blocked by HSPB1 suppression. ***P<0.001 vs control tachypaced (4 Hz). # P<0.001 vs control normal paced (1 Hz).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0020395.g003