Neurodevelopmental Disruption of Cortico-Striatal Function Caused by Degeneration of Habenula Neurons
Figure 9
(a) An example of shrinkage of the MHb with NNH. This example shows one of the largest MHb shrinkage, which accompanied with consequent structural change in the LHb. The blue, red, and green arrows indicate the MHb, LHb, and stria medullaris, respectively. Scale bar = 100 µm. (b) A Graph showing the ratio of the areas of the MHb over LHb in adult NNH and CTR rats. *P<0.001. (c) A graph showing locomotor distance of juvenile and adult NNH and CTR rats with SAL, or different doses of AMP (AMP0.5–4.0). *P<0.001, **P = 0.008, ***P = 0.002. (d) A graph showing a number of opened and enclosed arm entries in the EPM. **P = 0.019, **P = 0.023. (e) A graph showing time spent on exploration of objects. *P = 0.014, **P = 0.013. (f) A graph showing the volume of the PL. *P<0.001. The PL volume of NHL rats shown in Fig. 7c is included in this graph to illustrate difference between NNL and NHL treatments on PL volume reduction with development.