A Computational Model of the Ionic Currents, Ca2+ Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle
Figure 6
Steady-state properties of are derived from experimental data of myometrial longitudinal cells in late pregnant rats [17]; the kinetics are extracted from raw data tracings from myometrial cells of late pregnant women from Knock et al., [19] and Knock G & Aaronson P (personal communication, including unpublished time tracings - see Figure S5). A, V-dependent steady-states of activation (
) and inactivation (
). B, V-dependent activation time constants (
) C, V-dependent fast (
) and slow (
) inactivation time constants. The experimental fast (solid circles) and slow (empty circles) inactivation time constants were extracted from voltage-clamp time tracings averaged from four cells (1 published and 3 unpublished with the average values labeled as ‘Knock et al 1999+unpublished (Knock & Aaronson)’ in the figure. D, simulated I–V relationship of
from a holding potential of
and
with
and
; all values are normalized to the peak current at
from
. E, simulated time tracings of
at voltage steps of
to
from a holding potential of
; both simulated and experimental currents are normalized to the peak current at
; F, enlarged E showing activation of
during the first few hundred milli-seconds.