An Alternate STAT6-Independent Pathway Promotes Eosinophil Influx into Blood during Allergic Airway Inflammation
Figure 1
Characterization of eosinophilic inflammation in allergic lungs.
OVA/OVA treated WT mice had significantly increased numbers of eosinophils in (A) BALF and (B) peribronchial and perivascular regions of the lung, compared to SAL/OVA treated controls. The levels of BALF neutrophil in OVA/OVA treated STAT6-deficient mice were significantly higher than that in SAL/OVA WT control but less than that in OVA/OVA treated WT mice. No significant infiltration of eosinophils was observed in OVA/OVA treated STAT6-deficient mice, which were at the same levels as SAL/OVA treated WT mice. #P<0.05 compared to SAL/OVA treated WT, *P<0.05 compared to OVA/OVA treated WT mice.