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Gas6 Increases Myelination by Oligodendrocytes and Its Deficiency Delays Recovery following Cuprizone-Induced Demyelination

Figure 4

Expression of oligodendrocyte lineage markers are altered in the absence of Gas6 during remyelination.

Wild-type and Gas6 KO mice were subjected to cuprizone challenge for 5 weeks followed by recovery in the absence of cuprizone for 0, 2, 4 or 10 weeks. A. Representative images of the middle segment of the corpus callosum, showing cells positive for APC(CC1) or double positive for Olig2/PDGFRα. B–G. A significant reduction in the number of APC(CC1) positive cells was observed in the caudal segment of the corpus callosum in Gas6−/− mice compared with Gas6+/+ mice (p = 0.0070) (D). The density of Olig2+/PDGFRα+ OPCs was significantly increased in Gas6−/− mice compared with Gas6+/+ mice following both 4 and 10 weeks of remyelination (4 weeks, p = 0.024; 10 weeks, p = 0.003) (E). Scale bar = 20 µm.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0017727.g004