Directed Partial Correlation: Inferring Large-Scale Gene Regulatory Network through Induced Topology Disruptions
Figure 1
DPC for large-scale transcriptional regulatory network inference.
(a) DPC detects network topology changes with the addition of a gene, the inclusion of a transcription factor should lead to dramatic changes of the connectivity of its downstream targets, (b) module discovery in the large-scale DPC network by biclustering the network adjacency matrix, (c) functional analysis of the network modules reveals putative transcription factors active under the biological condition.