A Folding Pathway-Dependent Score to Recognize Membrane Proteins
Figure 3
The insertion step parameters.
The changes in parameters describing the insertion stage are shown for bacterial and vertebrate proteins. The vertical axes are the mean value of the corresponding parameter average for the window that slides along the protein sequence. A) The variation of ΔG(oct) is illustrated, which is a whole residue hydrophobicity scale and a sign of the protein membrane propensity. B) The alpha helix propensity is a measure of the tendency to form alpha helix, which is characterized by ΔΔG(α-helix). Ref. stands for the reference proteins. The error bars indicate the SEM for the parameters of each protein. The bar patterns represent Archea: wide upward diagonal, Eubacteria: dashed horizontal, Fishes: horizontal brick, Amphibia: white, Aves: wave, Mammalia: black, APHO 14A7L: black dotted white, APHO 16A5L: white grained black, APHO 18A3L: white dotted black, and APHO: gray dotted white.