Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor
Figure 4
Reduction of gamma oscillation power in KO mice is partially reversed by 5-HT3 receptor antagonist tropisetron.
A–B. Upper: Example traces of field oscillations in hippocampal area CA1 induced by carbachol in the presence of 30 nM tropisetron in slices from KO (KO+trop) (A) and WT (WT+trop) mice (B). Lower: Traces of oscillations obtained in the absence of tropisetron, are shown for comparison. C–D. Power spectra for oscillations in A (C) and B (D). E–F. Pooled data for integral oscillation power (20–80 Hz) in area CA1 in the presence of tropisetron (grey bars); data from Fig. 1 obtained in the absence of tropisetron are shown for comparison (white bars). Number of cells recorded from is indicated in parenthesis. **p<0.01. Data represent mean ± SEM.